Clinical studies
We participate in clinical drug trials, investigator-initiated studies and registries in stroke care and neurocritical care.
Current participation
Industry-sponsored research, investigator-initiated studies and registries. Status labels describe the overall study as reported by its registry; dates describe our participation.
RESPECT-ETB: Sovateltide in acute ischaemic stroke
Overall study: RecruitingIndustry-sponsored research, Phase 3, Local principal investigator
The study evaluates the safety and efficacy of sovateltide alongside standard care in acute ischaemic stroke, comparing sovateltide with placebo.
Our participation: Since Sept 2025Sponsor: Pharmazz, Inc.Registration NCT05691244 (opens in a new tab)
LIBREXIA-STROKE: Milvexian for prevention of recurrent stroke
Overall study: Active, not recruitingIndustry-sponsored research, Phase 3, Local principal investigator
The study tests whether the factor XIa inhibitor milvexian reduces the risk of recurrent ischaemic stroke compared with placebo after an ischaemic stroke or high-risk transient ischaemic attack (TIA).
Our participation: Since Mar 2024Sponsor: Janssen Research & Development, LLCRegistration NCT05702034 (opens in a new tab)
CoSIE_retro: Coagulation management in stroke due to infective endocarditis (opens in a new tab)
Investigator-initiated study / registry, Participating site
This multicentre retrospective study examines antithrombotic and anticoagulation management in infective endocarditis with ischaemic or haemorrhagic stroke, and its association with patient outcomes. It is an IGNITE! network project.
GSR-ET: German Stroke Registry – Endovascular Treatment (opens in a new tab)
Overall study: RecruitingInvestigator-initiated study / registry, Participating site
This independent, prospective registry records endovascular treatment of acute ischaemic stroke in routine care. It examines treatment practice, safety and outcomes up to 90 days after stroke.
Sponsor: University Medical Center Hamburg-EppendorfRegistration NCT03356392 (opens in a new tab)
PRAISE 2
Investigator-initiated study / registry, Participating site
PERFECT CUE: Pupillometry in coma of unknown aetiology
Overall study: Recruitment plannedInvestigator-initiated study / registry, Participating site
This prospective observational study examines whether quantitative pupillometry in the emergency department can help identify the cause of impaired consciousness of unknown aetiology. It records pupil measurements and routine-care data.
Sponsor: Ludwig Maximilian University of MunichRegistration DRKS00036028 (opens in a new tab)
STAR: Stroke Thrombectomy and Aneurysm Registry (opens in a new tab)
Overall study: RecruitingInvestigator-initiated study / registry, Participating site
This international registry records outcomes after thrombectomy and endovascular treatment of cerebrovascular diseases, including brain aneurysms. Routine-care data support research into treatment techniques and factors associated with outcomes.
Sponsor: Medical University of South CarolinaRegistration NCT04994756 (opens in a new tab)